interleukin-8 but not interleukin-6 variant may affect susceptibility to brucellosis

نویسندگان

sadaf asaei

department of immunology, professor alborzi clinical microbiology research center, shiraz university of medical sciences, shiraz manoochehr rasouli

department of immunology, professor alborzi clinical microbiology research center, shiraz university of medical sciences, shiraz ali moravej

department of immunology, fasa university of medical sciences, fasa, iran

چکیده

background: increased levels of interleukin-8 (il-8) and interleukin-6 (il-6) in acute human brucellosis have been reported. previous studies have shown that the production and level of il-6 and il-8 cytokines are associated with the polymorphism of the encoding genes. objective: to investigate the probable association between il-6 (-174 c/g) and il-8 (-251 a/t) gene polymorphisms and susceptibility/resistance to brucellosis. methods: the patient group included 196 patients suffering from brucella infection and the control group consisted of 82 healthy animal husbandmen from the same geographical area. il-8 (-251 a/c) and il-6 (-174 c/g) gene polymorphisms were analyzed by pcr-rflp and allele specific pcr (as-pcr) respectively. results: the frequency of -251 il-8 aa genotype was significantly lower in the controls compared with that of the patients (p=0.0051), while the frequencies of other genotypes (at and tt) and alleles (a and t) were not significantly different among the participants. no association was found between il-6 (-174 c/g) polymorphism and brucellosis. conclusion: this study indicates that the il-8 -251 aa genotype may be considered as a genetic susceptibility factor for brucellosis.

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عنوان ژورنال:
iranian journal of immunology

جلد ۱۰، شماره ۳، صفحات ۱۵۸-۱۶۶

کلمات کلیدی
[ ' b r u c e l l o s i s ' , ' i n t e r l e u k i n ' , 6 , ' i n t e r l e u k i n ' , 8 , ' p o l y m o r p h i s m ' ]

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